The Australian college has 4 million in funding and feel they are close to a breakthrough in marketing a biomarker for widespread use, and then treatment.
- SNPS in acetylcholine receptors Examination of single nucleotide polymorphisms in acetylcholine receptors in chronic fatigue syndrome patients
- SNPS in ‘threat’ receptors Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients
- Mast cell precursors increased and active in the peripheral blood Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients
- One of the transient potential receptors (TRPM3) appears critical to NK function Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients
- TRPA1 ion channel detects oxidative stress, endogenous and exogenous chemicals such as smoke, solvents, cold air, electrophiles such as fluoride chlorine and iodine. Olopatadine (patanese/patanol) can work in trigeminal response to reduce fogginess Olopatadine 0.6% nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis.
Of their findings, team said:
-TRPM3 receptors have been identified on these particular immune cells, not only in healthy people for the first time, but also have been shown to be significantly reduced in CFS/ME patients. These receptors are important as they move calcium inside the cell. Interestingly in this study, also a significant reduction of calcium inside these cells from CFS/ME patients.’ Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients
The findings regarding calcium dysfunction are interesting in relation to what many have found
- In patient groups of both ME/CFS and fibromyalgia magnesium is usually well tolerated and brings symptomatic relief
- Naturopaths have used magnesium extensively in patients with a stress as part of what is labelled ‘adrenal fatigue’ which has many cross overs eg sleep, gut and orthostatic dysfunction
- Tietlebaum’s protocol for ‘fibromyalgia’ (which conflates CFS & fibro) says the issue is calcium signalling and being stuck in the cells, leaving the muscles in a perpetual state of activation, which exhausted them.