The Australian college has 4 million in funding and feel they are close to a breakthrough in marketing a biomarker for widespread use, and then treatment.

Of their findings, team said:

-TRPM3 receptors have been identified on these particular immune cells, not only in healthy people for the first time, but also have been shown to be significantly reduced in CFS/ME patients. These receptors are important as they move calcium inside the cell. Interestingly in this study, also a significant reduction of calcium inside these cells from CFS/ME patients.’ Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients

The findings regarding calcium dysfunction are interesting in relation to what many have found

  • In patient groups of both ME/CFS and fibromyalgia magnesium is usually well tolerated and brings symptomatic relief
  • Naturopaths have used magnesium extensively in patients with a stress as part of what is labelled ‘adrenal fatigue’ which has many cross overs eg sleep, gut and orthostatic dysfunction
  • Tietlebaum’s protocol for ‘fibromyalgia’ (which conflates CFS & fibro) says the issue is calcium signalling and being stuck in the cells, leaving the muscles in a perpetual state of activation, which exhausted them.
  • Update

  • NCNEDs publications continue: TRPM3 activity is impaired in CFS/ME patients suggesting changes in intracellular Ca2+ concentration, which may impact NK cellular functions. Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
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